Testing the Sensitivity of Tract-Based Spatial Statistics to Simulated Treatment Effects in Preterm Neonates
Gareth Ball, James P Boardman, Tomoki Arichi, Nazakat Merchant, Daniel Rueckert, A David Edwards, Serena J Counsell
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2013
Early neuroimaging may provide a surrogate marker for brain development and outcome after preterm birth. Tract-Based Spatial Statistics (TBSS) is an advanced Diffusion Tensor Image (DTI) analysis technique that is sensitive to the effects of prematurity and may provide a quantitative marker for neuroprotection following perinatal brain injury or preterm birth. Here, we test the sensitivity of TBSS to detect diffuse microstructural differences in the developing white matter of preterm infants at term-equivalent age by modelling a 'treatment' effect as a global increase in fractional anisotropy (FA). As proof of concept we compare these simulations to a real effect of increasing age at scan. 3..View full abstract
Awarded by Medical Research Council
This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, and at Imperial College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. Funding for the research was supplied by MRC, EPSRC and the Garfield Weston Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.