Journal article

The influence of preterm birth on the developing thalamocortical connectome

Gareth Ball, James P Boardman, Paul Aljabar, Anand Pandit, Tomoki Arichi, Nazakat Merchant, Daniel Rueckert, A David Edwards, Serena J Counsell

Cortex | ELSEVIER MASSON, CORP OFF | Published : 2013

Abstract

INTRODUCTION: Defining connectivity in the human brain signifies a major neuroscientific goal. Advanced imaging techniques have enabled the non-invasive tracing of brain networks to define the human connectome on a millimetre-scale. During early development, the brain undergoes significant changes that are likely represented in the developing connectome, and preterm birth represents a significant environmental risk factor that impacts negatively on early cerebral development. Using tractography to comprehensively map the connections of the thalamocortical unit, we aim to demonstrate that premature extrauterine life due to preterm delivery results in significantly decreased thalamocortical co..

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Grants

Awarded by Engineering and Physical Sciences Research Council


Awarded by Medical Research Council


Awarded by National Institute for Health Research


Awarded by Action Medical Research


Funding Acknowledgements

We are grateful for support from the Imperial College Healthcare Comprehensive Biomedical Research Centre Funding Scheme, the Medical Research Council (UK) and the Academy of Medical Sciences for research grant support. We thank the families who took part in the study and our colleagues in the Neonatal Intensive Care Unit at Queens Charlotte's and Chelsea Hospital.