Journal article

Rich-club organization of the newborn human brain

Gareth Ball, Paul Aljabar, Sally Zebari, Nora Tusor, Tomoki Arichi, Nazakat Merchant, Emma C Robinson, Enitan Ogundipe, Daniel Rueckert, A David Edwards, Serena J Counsell

Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2014

Abstract

Combining diffusion magnetic resonance imaging and network analysis in the adult human brain has identified a set of highly connected cortical hubs that form a "rich club"--a high-cost, high-capacity backbone thought to enable efficient network communication. Rich-club architecture appears to be a persistent feature of the mature mammalian brain, but it is not known when this structure emerges during human development. In this longitudinal study we chart the emergence of structural organization in mid to late gestation. We demonstrate that a rich club of interconnected cortical hubs is already present by 30 wk gestation. Subsequently, until the time of normal birth, the principal development..

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Grants

Awarded by Engineering and Physical Sciences Research Council


Awarded by Medical Research Council


Awarded by National Institute for Health Research


Awarded by Action Medical Research


Funding Acknowledgements

Support for this work was provided from the Medical Research Council, Engineering and Physical Sciences Research Council, National Institute for Health Research Comprehensive Biomedical Research Centre awards to Guy's and St Thomas' National Health Service Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust, and the Garfield Weston Foundation.