Journal article

Thalamocortical Connectivity Predicts Cognition in Children Born Preterm

Gareth Ball, Libuse Pazderova, Andrew Chew, Nora Tusor, Nazakat Merchant, Tomoki Arichi, Joanna M Allsop, Frances M Cowan, A David Edwards, Serena J Counsell

Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2015

Abstract

Thalamocortical connections are: essential for brain function, established early in development, and significantly impaired following preterm birth. Impaired cognitive abilities in preterm infants may be related to disruptions in thalamocortical connectivity. The aim of this study was to test the hypothesis: thalamocortical connectivity in the preterm brain at term-equivalent is correlated with cognitive performance in early childhood. We examined 57 infants who were born <35 weeks gestational age (GA) and had no evidence of focal abnormality on magnetic resonance imaging (MRI). Infants underwent diffusion MRI at term and cognitive performance at 2 years was assessed using the Bayley III sca..

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Grants

Awarded by Medical Research Council (UK)


Awarded by Medical Research Council


Awarded by National Institute for Health Research


Funding Acknowledgements

This work was supported by the Medical Research Council (UK) (grant no: MR/K006355/1), the National Institute for Health Research Comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust, and Imperial College Healthcare Comprehensive Biomedical Research Centre Funding Scheme. Funding to pay the Open Access publication charges for this article was provided by the Medical Research Council (UK).