Analysis of continuous infusion functional PET (fPET) in the human brain
Shenpeng Li, Sharna D Jamadar, Phillip GD Ward, Malin Premaratne, Gary F Egan, Zhaolin Chen
NeuroImage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020
Functional positron emission tomography (fPET) is a neuroimaging method involving continuous infusion of 18-F-fluorodeoxyglucose (FDG) radiotracer during the course of a PET examination. Compared with the conventional bolus administration of FDG in a static PET scan, which provides an average glucose uptake into the brain over an extended period of up to 30 min, fPET offers a significantly higher temporal resolution to study the dynamics of glucose uptake. Several earlier studies have applied fPET to investigate brain FDG uptake and study its relationship with functional magnetic resonance imaging (fMRI). However, due to the unique characteristics of fPET signals, modelling of the fPET sign..View full abstract
Awarded by Australian Research Council (ARC)
Awarded by ARC Centre of Excellence for Integrative Brain Function
Awarded by Australian Research Council Discovery Early Career Research Award
This research was supported by funding to Z. Chen and S. Li from the Reignwood Cultural Foundation, and by funding from an Australian Research Council (ARC) Linkage grant (LP170100494) that includes financial support from Siemens Healthineers. GE is supported by the ARC Centre of Excellence for Integrative Brain Function (CE140100007). S.D. Jamadar is supported by an Australian Research Council Discovery Early Career Research Award (DE150100406). The authors are grateful to Richard McIntyre, Alexandra Carey and Jason Bradley from Monash Biomedical Imaging for assistance in acquiring data, Edwina Orchard, Irene Graafsma and Disha Sasan for assistance with the collection of data, Shenjun Zhong for assistance in software preparation, Francesco Sforazzini and Jakub Baran for assistance in the PET data post-processing, and Keiran O'Brien and Daniel Staeb from Siemens Healthineers for useful discussions and the provision of e7tools software.