Journal article

Blood Pressure Drop Rate After Standing Up Is Associated With Frailty and Number of Falls in Geriatric Outpatients

Arjen Mol, Lois Robin Nicolle Slangen, Marijke C Trappenburg, Esmee M Reijnierse, Richard JA van Wezel, Carel GM Meskers, Andrea B Maier

Journal of the American Heart Association | WILEY | Published : 2020


Background The relationship between orthostatic hypotension and clinical outcome in older adults is poorly understood. Blood pressure drop rate (ie, speed of blood pressure drop) may particularly reflect the imposed challenge to the baroreflex and the associated clinical outcome (ie, frailty and number of falls). This study aimed to compare orthostatic blood pressure drop rate and drop magnitude with regard to their association with frailty and number of falls. Methods and Results Blood pressure was measured continuously during a standardized active stand task in 168 patients (mean age 81.4±7.0; 55.4% female) who visited a geriatric outpatient clinic for cognitive or mobility problems. The a..

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Awarded by perspective grant (NeuroCIMT) of the Applied and Engineering Sciences part of the Netherlands Organization for Scientific Research (NWO, Utrecht, the Netherlands)

Awarded by European Union

Funding Acknowledgements

This study has received funding from the perspective grant (NeuroCIMT, No. 14901) of the Applied and Engineering Sciences, which is part of the Netherlands Organization for Scientific Research (NWO, Utrecht, the Netherlands), and which is partly funded by the Ministry of Economic Affairs. Furthermore, this study was supported by the European Union's Horizon 2020 research and innovation programs PreventIT (No. 689238) and PANINI (No. 675003). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.