Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

J Shin; S Ma; E Hofer; Y Patel; DE Vosberg; S Tilley; GV Roshchupkin; AMM Sousa; X Jian; R Gottesman; TH Mosley; M Fornage; Y Saba; L Pirpamer; R Schmidt; H Schmidt; A Carrion-Castillo; F Crivello; B Mazoyer; JC Bis; S Li; Q Yang; M Luciano; S Karama; L Lewis; ME Bastin; MA Harris; JM Wardlaw; IE Deary; M Scholz; M Loeffler; AV Witte; F Beyer; A Villringer; NJ Armstrong; KA Mather; D Ames; J Jiang; JB Kwok; PR Schofield; A Thalamuthu; JN Trollor; MJ Wright; H Brodaty; W Wen; PS Sachdev; N Terzikhan; TE Evans; HHHH Adams; MA Ikram; S Frenzel; S van der Auwera-Palitschka; K Wittfeld; R Bülow; HJ Grabe; C Tzourio; A Mishra; S Maingault; S Debette; NA Gillespie; CE Franz; WS Kremen; L Ding; N Jahanshad; N Sestan; Z Pausova; S Seshadri; T Paus

Journal article

Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

J Shin, S Ma, E Hofer, Y Patel, DE Vosberg, S Tilley, GV Roshchupkin, AMM Sousa, X Jian, R Gottesman, TH Mosley, M Fornage, Y Saba, L Pirpamer, R Schmidt, H Schmidt, A Carrion-Castillo, F Crivello, B Mazoyer, JC Bis Show all

Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2020

DOI: 10.1093/CERCOR/BHAA035

Abstract

We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity path..

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