Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes
Jean Shin, Shaojie Ma, Edith Hofer, Yash Patel, Daniel E Vosberg, Steven Tilley, Gennady Roshchupkin, Andre MM Sousa, Xueqiu Jian, Rebecca Gottesman, Thomas H Mosley, Myriam Fornage, Yasaman Saba, Lukas Pirpamer, Reinhold Schmidt, Helena Schmidt, Amaia Carrion-Castillo, Fabrice Crivello, Bernard Mazoyer, Joshua C Bis Show all
Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2020
We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity path..View full abstract
This research has been conducted using the UK Biobank Resource under Application Numbers 23509 and 43688.