Journal article

Secreted TAL effectors protect symbiotic bacteria from entrapment within fungal hyphae

Ingrid Richter, Zerrin Uzum, Claire Stanley, Nadine Moebius, Timothy Stinear, Sacha Pidot, Iuliia Ferling, Falk Hillmann, Christian Hertweck

Cold Spring Harbor Laboratory | Published : 2020

Abstract

The association of the agriculturally significant phytopathogenic fungus Rhizopus microsporus with the bacterial endosymbiont Burkholderia rhizoxinica is a remarkable example of bacteria controlling host physiology and reproduction. Here, we show that a group of transcription activator-like effectors (TALEs) called Burkholderia TALE-like proteins (BATs) from B. rhizoxinica are essential for the establishment of the symbiosis. Mutants lacking BAT proteins are unable to induce host sporulation. Utilising novel microfluidic devices in combination with fluorescence microscopy we observed the accumulation of BAT-deficient mutants in specific fungal side-hyphae with accompanying increased fungal r..

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