Journal article

Mechanisms of Chronotropic Incompetence in Heart Failure With Preserved Ejection Fraction.

Satyam Sarma, Douglas Stoller, Joseph Hendrix, Erin Howden, Justin Lawley, Sheryl Livingston, Beverley Adams-Huet, Courtney Holmes, David S Goldstein, Benjamin D Levine

Circ Heart Fail | Published : 2020

Abstract

BACKGROUND: Chronotropic incompetence is common in heart failure with preserved ejection fraction (HFpEF) and is associated with impaired aerobic capacity. We investigated the integrity of cardiac β-receptor responsiveness, an important mechanism involved in exertional increases in HR, in HFpEF and control subjects. METHODS: Thirteen carefully screened patients with HFpEF and 13 senior controls underwent exercise testing and graded isoproterenol infusion to quantify cardiac β-receptor-mediated HR responses. To limit autonomic neural influences on heart rate (HR) during isoproterenol, dexmedetomidine and glycopyrrolate were given. Isoproterenol doses were increased incrementally until HR incr..

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