Mechanisms of Chronotropic Incompetence in Heart Failure With Preserved Ejection Fraction.
Satyam Sarma, Douglas Stoller, Joseph Hendrix, Erin Howden, Justin Lawley, Sheryl Livingston, Beverley Adams-Huet, Courtney Holmes, David S Goldstein, Benjamin D Levine
Circ Heart Fail | Published : 2020
BACKGROUND: Chronotropic incompetence is common in heart failure with preserved ejection fraction (HFpEF) and is associated with impaired aerobic capacity. We investigated the integrity of cardiac β-receptor responsiveness, an important mechanism involved in exertional increases in HR, in HFpEF and control subjects. METHODS: Thirteen carefully screened patients with HFpEF and 13 senior controls underwent exercise testing and graded isoproterenol infusion to quantify cardiac β-receptor-mediated HR responses. To limit autonomic neural influences on heart rate (HR) during isoproterenol, dexmedetomidine and glycopyrrolate were given. Isoproterenol doses were increased incrementally until HR incr..View full abstract
Awarded by NIA NIH HHS