A Simple Clinical Tool for Stratifying Risk of Clinically Significant CKD after Nephrectomy: Development and Multinational Validation
Robert J Ellis, Sharon J Del Vecchio, Kevin MJ Gallagher, Danielle N Aliano, Neil Barber, Damien M Bolton, Etienne TS Chew, Jeff S Coombes, Michael D Coory, Ian D Davis, James F Donaldson, Ross S Francis, Graham G Giles, Glenda C Gobe, Carmel M Hawley, David W Johnson, Alexander Laird, Steve Leung, Manar Malki, David JT Marco Show all
Journal of the American Society of Nephrology | AMER SOC NEPHROLOGY | Published : 2020
BACKGROUND: Clinically significant CKD following surgery for kidney cancer is associated with increased morbidity and mortality, but identifying patients at increased CKD risk remains difficult. Simple methods to stratify risk of clinically significant CKD after nephrectomy are needed. METHODS: To develop a tool for stratifying patients' risk of CKD arising after surgery for kidney cancer, we tested models in a population-based cohort of 699 patients with kidney cancer in Queensland, Australia (2012-2013). We validated these models in a population-based cohort of 423 patients from Victoria, Australia, and in patient cohorts from single centers in Queensland, Scotland, and England. Eligible p..View full abstract
Awarded by National Health and Medical Research Council
Awarded by Victorian Cancer Agency translational research grant
Prof. Davis was supported by a National Health and Medical Research Council fellowship APP1102604. Dr. Ellis was supported by an Australian Government Research training stipend. Prof. Jordan was supported by a National Health and Medical Research Council fellowship APP1061341. Prof. Neale was supported by a National Health and Medical Research Council fellowship APP1043029. Australian population-based data collection was funded through Victorian Cancer Agency translational research grant EOI09_E36 and a Cancer Council Queensland project grant.