Assessing the Effects of Parthenolide on Inflammation, Bone Loss, and Glial Cells within a Collagen Antibody-Induced Arthritis Mouse Model
B Williams, F Lees, H Tsangari, MR Hutchinson, E Perilli, TN Crotti
MEDIATORS OF INFLAMMATION | HINDAWI LTD | Published : 2020
Rheumatoid arthritis is characterised by a chronic inflammatory response resulting in destruction of the joint and significant pain. Although a range of treatments are available to control disease activity in RA, bone destruction and joint pain exist despite suppression of inflammation. This study is aimed at assessing the effects of parthenolide (PAR) on paw inflammation, bone destruction, and pain-like behaviour in a mild collagen antibody-induced arthritis (CAIA) mouse model. CAIA was induced in BALB/c mice and treated daily with 1 mg/kg or 4 mg/kg PAR. Clinical paw inflammation was scored daily, and mechanical hypersensitivity was assessed on alternate days. At end point, bone volume and..View full abstract
Awarded by Australian Research Council
We would like to acknowledge Adelaide Microscopy at the University of Adelaide for the imaging advice, the University of Adelaide Animal Laboratory Services for the assistance with the animal model, and the Histology Laboratory at the University of Adelaide for their assistance with processing and cutting tissues. MRH is a recipient of an Australian Research Council Research fellowship (DP110100297 up to 2016) and Future Fellowship (FT180100565 from 2018). FL is a recipient of the University of Adelaide Faculty of Health and Medical Science's Divisional Scholarship and the Commonwealth Scholarships Program for South Australia. BW is a recipient of the Australian Government Research Training Program Scholarship. This project was kindly funded by Arthritis Australia (Dr. Tania N Crotti).