Journal article

Cross-talk between tumors at anatomically distinct sites

Amanda J Oliver, Phillip K Darcy, Joseph A Trapani, Michael H Kershaw, Clare Y Slaney

The FEBS Journal | WILEY | Published : 2020

Abstract

Cancer tissue is not homogenous, and individual metastases at different anatomical locations can differ from the primary tumor and from one another in both their morphology and cellular composition, even within an individual patient. Tumors are composed of cancer cells and a range of other cell types, which, together with a variety of secreted molecules, collectively comprise the tumor microenvironment. Cells of the tumor microenvironment can communicate with each other and with distant tissues in a form of molecular cross-talk to influence their growth and function. Cross-talk between cancer cells and local immune cells is well described, and can lead to the induction of local immunosuppres..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by National Breast Cancer Foundation (NBCF) of Australia


Awarded by Susan G. Komen Breast Cancer Foundation


Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia (1103352 and 1176935), the National Breast Cancer Foundation (NBCF) of Australia (IIRS-18-064 and IIRS-20-073), and Susan G. Komen Breast Cancer Foundation (16376637). PKD was supported by a Principal Research Fellowship from the NHMRC. CYS was supported by a Postdoctoral Fellowship from the NBCF. JAT is a Rosie Lew Fellow of the Peter MacCallum Cancer Foundation.