Childhood trauma, midbrain activation and psychotic symptoms in borderline personality disorder.
K Nicol, M Pope, L Romaniuk, J Hall
Translational Psychiatry | Springer Science and Business Media LLC | Published : 2015
Childhood trauma is believed to contribute to the development of borderline personality disorder (BPD), however the mechanism by which childhood trauma increases risk for specific symptoms of the disorder is not well understood. Here, we explore the relationship between childhood trauma, brain activation in response to emotional stimuli and psychotic symptoms in BPD. Twenty individuals with a diagnosis of BPD and 16 healthy controls were recruited to undergo a functional MRI scan, during which they viewed images of faces expressing the emotion of fear. Participants also completed the childhood trauma questionnaire (CTQ) and a structured clinical interview. Between-group differences in brain ..View full abstract
Awarded by Medical Research Council
Awarded by Chief Scientist Office
Awarded by Wellcome Trust