White matter integrity and its association with affective and interpersonal symptoms in borderline personality disorder.
Heather C Whalley, Thomas Nickson, Merrick Pope, Katie Nicol, Liana Romaniuk, Mark E Bastin, Scott I Semple, Andrew M McIntosh, Jeremy Hall
NeuroImage Clinical | Elsevier BV | Published : 2015
BACKGROUND: Borderline personality disorder (BPD) is a severe psychiatric disorder involving a range of symptoms including marked affective instability and disturbances in interpersonal interactions. Neuroimaging studies are beginning to provide evidence of altered processing in fronto-limbic network deficits in the disorder, however, few studies directly examine structural connections within this circuitry together with their relation to proposed causative processes and clinical features. METHODS: In the current study, we investigated whether individuals with BPD (n = 20) have deficits in white matter integrity compared to a matched group of healthy controls (n = 18) using diffusion tensor ..View full abstract
Awarded by Wellcome Trust
Awarded by Medical Research Council
Awarded by Chief Scientist Office