The Methylation of DNA Repeat Elements is Sex-Dependent and Temporally Different in Response to X Radiation in Radiosensitive and Radioresistant Mouse Strains
Michelle R Newman, Pamela J Sykes, Benjamin J Blyth, Eva Bezak, Mark D Lawrence, Katherine L Morel, Rebecca J Ormsby
RADIATION RESEARCH | RADIATION RESEARCH SOC | Published : 2014
The effects of ionizing radiation on DNA methylation are of importance due to the role that DNA methylation plays in maintaining genome stability, and the presence of aberrant DNA methylation in many cancers. There is limited evidence that radiation-sensitivity may influence the modulation of DNA methylation by ionizing radiation, resulting in a loss of methylation. The BALB/c, CBA and C57Bl/6 strains are the most commonly utilized mouse strains in radiation research and are classified as radiation sensitive (BALB/c and CBA) or radiation resistant (C57Bl/6). We present here the first direct comparison of changes in repeat element DNA methylation (L1, B1 and Intracisternal A Particle; IAP) ov..View full abstract
Awarded by Low Dose Radiation Research Program, Biological and Environmental Research, U.S. Department of Energy
We wish to thank Ami-Louise Cochrane and Dr. Alex Staudacher for assistance with animal procedures. This work was supported by the Low Dose Radiation Research Program, Biological and Environmental Research, U.S. Department of Energy (DE-FG02-05ER64104); the Flinders Medical Centre/Flinders Centre for Innovation in Cancer Research Grant; and the Flinders Medical Centre Foundation and BHP Billiton Low Dose Radiation Research Scholarship (to MN).