Journal article

Co-operative effects of thoracic X-ray irradiation and N-nitrosobis(2-hydroxypropyl) amine administration on lung tumorigenesis in neonatal, juvenile and adult Wistar rats

Ken-ichi Iwata, Yutaka Yamada, Akifumi Nakata, Yoichi Oghiso, Shusuke Tani, Kazutaka Doi, Takamitsu Morioka, Benjamin J Blyth, Mayumi Nishimura, Shizuko Kakinuma, Yoshiya Shimada

TOXICOLOGY AND APPLIED PHARMACOLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2013

Abstract

Assessment of risks associated with childhood exposure to ionizing radiation when combined with chemical carcinogens is of great importance. We studied the age-dependence of the effect of combined exposure to ionizing radiation (IR) and a chemical carcinogen on lung carcinogenesis. Female 1-, 5-, and 22-week-old Wistar rats were locally irradiated on the thorax with X-rays (3.18 Gy) and/or were injected intraperitoneally with N-nitrosobis(2-hydroxypropyl)amine (BHP) (1g/kg body weight) 1 week after X-ray exposure or at 23 weeks of age. Rats were terminated at 90 weeks of age. We found that: (i) the incidence of lung tumors (adenoma and adenocarcinoma) increased slightly as a function of age ..

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