Theranostic implications of molecular imaging phenotype of well-differentiated pulmonary carcinoid based on(68)Ga-DOTATATE PET/CT and(18)F-FDG PET/CT
Lamiaa Zidan, Amir Iravani, Grace Kong, Tim Akhurst, Michael Michael, Rodney J Hicks
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | SPRINGER | Published : 2020
PURPOSE: This study aimed to analyse the molecular imaging (MI) phenotype of typical carcinoid (TC) and atypical carcinoid (AC) by 68Ga-DOTATATE (GaTATE) and 18F-FDG (FDG) PET/CT with the emphasis on its potential theranostic implications for peptide receptor radionuclide therapy (PRRT). METHODS: Retrospective review of patients with biopsy-proven TC or AC undergoing both GaTATE and FDG PET/CT at presentation. Based on correlative CT or MRI, positive lesions on either scan were defined by uptake above liver parenchyma. Per patient MI phenotypic pattern was classified as score 1, if all lesions were negative on both scans; score 2, if all were GaTATE positive/FDG negative; score 3, if all les..View full abstract
Awarded by NHMRC Practitioner Fellowship of the Australian Health and Medical Research Foundation
This work was partly funded by the Peter Mac Foundation and supported by an NHMRC Practitioner Fellowship of the Australian Health and Medical Research Foundation to Professor Hicks (APP1108050).