Journal article

Carboplatin dosing in the era of IDMS-creatinine; the Cockroft-Gault formula no longer provides a sufficiently accurate estimate of glomerular filtration rate for routine use in clinical care

Luke McLean, James R Whittle, Jonathan Graham, Huda Ismail, Meir Lichtenstein, Rodney J Hicks, Orla McNally, Alan Herschtal, Mark Rosenthal, Danny Rischin, Anne Hamilton

Gynecologic Oncology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020


BACKGROUND: Glomerular filtration rate (GFR) measured by Chromium-51-EDTA excretion (51Cr-GFR) is considered the gold standard of renal function assessment, but serum creatinine in the Cockcroft-Gault (CG) formula is routinely used to estimate GFR for carboplatin dosing. Serum creatinine measured by isotope-dilution-mass-spectrometry (IDMS) can generate spuriously high GFR estimates when used in the CG formula. We hypothesized that GFR calculated using IDMS-creatinine in the CG formula (CG-GFR) exposes patients to inaccurate carboplatin dosing. METHODS: This is a multicenter retrospective study of patients who had a 51Cr-GFR assessment for malignant or non-malignant indications, with a match..

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