Journal article

Diagnostic Yield of Initial and Consecutive Blood Cultures in Children With Cancer and Febrile Neutropenia

Gabrielle M Haeusler, Richard De Abreu Lourenco, Hannah Clark, Karin A Thursky, Monica A Slavin, Franz E Babl, Francoise Mechinaud, Frank Alvaro, Julia Clark, Bhavna Padhye, Marianne Phillips, Leanne Super, Heather Tapp, Thomas Walwyn, David Ziegler, Robert Phillips, Leon J Worth

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | OXFORD UNIV PRESS | Published : 2021

Abstract

BACKGROUND: The timing and necessity of repeated blood cultures (BCs) in children with cancer and febrile neutropenia (FN) are unknown. We evaluated the diagnostic yield of BCs collected pre- and post-empiric FN antibiotics. METHODS: Data collected prospectively from the Australian Predicting Infectious ComplicatioNs in Children with Cancer (PICNICC) study were used. Diagnostic yield was calculated as the number of FN episodes with a true bloodstream infection (BSI) detected divided by the number of FN episodes that had a BC taken. RESULTS: A BSI was identified in 13% of 858 FN episodes. The diagnostic yield of pre-antibiotic BCs was higher than of post-antibiotic cultures (12.3% vs 4.4%, P ..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Victorian Cancer Agency early career fellowship


Funding Acknowledgements

This work was supported by a National Health and Medical Research Council project grant (APP1104527) and a Victorian Cancer Agency early career fellowship (ECHSRF18024 to G. M. H.).