Regional neurodegeneration correlates with sleep-wake dysfunction after stroke
Elie Gottlieb, Natalia Egorova, Mohamed S Khlif, Wasim Khan, Emilio Werden, Matthew P Pase, Mark Howard, Amy Brodtmann
Sleep | OXFORD UNIV PRESS INC | Published : 2020
Sleep-wake disruption is a key modifiable risk factor and sequela of stroke. The pathogenesis of poststroke sleep dysfunction is unclear. It is not known whether poststroke sleep pathology is due to focal infarction to sleep-wake hubs or to accelerated poststroke neurodegeneration in subcortical structures after stroke. We characterize the first prospective poststroke regional brain volumetric and whole-brain, fiber-specific, white matter markers of objectively measured sleep-wake dysfunction. We hypothesized that excessively long sleep (>8 h) duration and poor sleep efficiency (<80%) measured using the SenseWear Armband 3-months poststroke (n = 112) would be associated with reduced regional..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by Australian Research Council
This work was supported by the National Health and Medical Research Council project grant (APP1020526), the Brain Foundation, Wicking Trust, Collie Trust, and Sidney and Fiona Myer Family Foundation. N.E. was supported by the Australian Research Council Discovery Early Career Researcher Award DE180100893.