Prion disease in Indigenous Australians.
Peter K Panegyres, Christiane Stehmann, Genevieve M Klug, Colin L Masters, Steven Collins
Internal Medicine Journal | Published : 2020
BACKGROUND: Indigenous Australians are of increased risk of developing dementia - Alzheimer's disease and mixed dementia diagnoses are the most common. Whilst prion diseases have been reported in Indigenous peoples of Papua New Guinea and the United States of America, the occurrence and phenotype of prion disease in Indigenous Australians is hitherto unreported. AIM: Report the incidence rate and clinical phenotype of Creutzfeldt-Jakob disease (CJD) in Indigenous Australians. METHOD: Calculation of crude sporadic CJD (sCJD) incidence rates and indirect age-standardisation of all CJD to calculate the standardised mortality ratio (SMR) for the Indigenous Australian population in comparison to ..View full abstract