Journal article

Fibroblastic Subtype has a Favourable Prognosis in Appendicular Osteosarcoma of Dogs

AA Al-Khan, JS Nimmo, MJ Day, M Tayebi, SD Ryan, CA Kuntz, JO Simcock, R Tarzi, ES Saad, SJ Richardson, JA Danks

Journal of Comparative Pathology | ELSEVIER SCI LTD | Published : 2020

Abstract

Osteosarcoma (OS) is an aggressive malignant bone neoplasm that occurs mostly in the appendicular skeleton of dogs and people. OS is classified based on the presence of malignant stroma and the formation of extracellular matrix into osteoblastic, chondroblastic and fibroblastic forms. This study investigated the correlation between the three histological subtypes of canine OS and clinical outcome. Additionally, we examined whether there was any difference in the immunolabelling of desmin, S100 and neuron-specific enolase (NSE) between the three histological subtypes. Formalin-fixed and paraffin wax-embedded tissues from 87 dogs with primary OS were available for this study. The survival time..

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Grants

Funding Acknowledgements

The authors acknowledge funding provided by the Ministry of Higher Education, Sultanate of Oman, and by the School of Health and Biomedical Sciences, RMIT University, Australia. The authors thank the veterinary clinics in Melbourne that supported this research and provided survival time data. We thank Dr S. Stylianou from the School of Science, RMIT University, for expertise in statistics and A. Barimah for assistance.