Journal article

Mycoplasma gallisepticum strain is-304 is a safe and effective live attenuated vaccine for use in chickens

Anna Kanci Condello, Gregory J Underwood, Pollob K Shil, Amir H Noormohammadi, Philip F Markham, Nadeeka K Wawegama, Glenn F Browning

Veterinary Microbiology | ELSEVIER | Published : 2020

Abstract

Vaxsafe MG (strain ts-11) is a live attenuated vaccine against the important poultry pathogen Mycoplasma gallisepticum that has been used globally to improve poultry health. However, the majority of the bacterial cells in Vaxsafe MG do not express the GapA cytadhesin, reducing their capacity to colonise the respiratory tract. Vaxsafe MG (strain ts-304) is a GapA positive clone recovered from Vaxsafe MG (strain ts-11) that has been shown to be safe and efficacious in turkeys, and preliminary studies have suggested that Vaxsafe MG (strain ts-304) may have greater efficacy in chickens than Vaxsafe MG (ts-11). The studies described here aimed to meet the international regulatory requirements for..

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