Journal article

Developing a multivariable prediction model for functional outcome after reperfusion therapy for acute ischaemic stroke: study protocol for the Targeting Optimal Thrombolysis Outcomes (TOTO) multicentre cohort study

Elizabeth Holliday, Thomas Lillicrap, Timothy Kleinig, Philip MC Choi, Jane Maguire, Andrew Bivard, Lisa F Lincz, Monica Anne Hamilton-Bruce, Sushma R Rao, Marten F Snel, Paul J Trim, Longting Lin, Mark W Parsons, Bradford B Worrall, Simon Koblar, John Attia, Chris Levi

BMJ Open | BMJ PUBLISHING GROUP | Published : 2020

Abstract

INTRODUCTION: Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) is the only approved pharmacological reperfusion therapy for acute ischaemic stroke. Despite population benefit, IVT is not equally effective in all patients, nor is it without significant risk. Uncertain treatment outcome prediction complicates patient treatment selection. This study will develop and validate predictive algorithms for IVT response, using clinical, radiological and blood-based biomarker measures. A secondary objective is to develop predictive algorithms for endovascular thrombectomy (EVT), which has been proven as an effective reperfusion therapy since study inception. METHODS ..

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