Journal article
Real-Time Image Guided Ablative Prostate Cancer Radiation Therapy: Results From the TROG 15.01 SPARK Trial
P Keall, DT Nguyen, R O'Brien, E Hewson, H Ball, P Poulsen, J Booth, P Greer, P Hunter, L Wilton, R Bromley, J Kipritidis, T Eade, A Kneebone, G Hruby, T Moodie, A Hayden, S Turner, S Arumugam, M Sidhom Show all
International Journal of Radiation Oncology Biology Physics | ELSEVIER SCIENCE INC | Published : 2020
Abstract
Purpose: Kilovoltage intrafraction monitoring (KIM) is a novel software platform implemented on standard radiation therapy systems and enabling real-time image guided radiation therapy (IGRT). In a multi-institutional prospective trial, we investigated whether real-time IGRT improved the accuracy of the dose patients with prostate cancer received during radiation therapy. Methods and Materials: Forty-eight patients with prostate cancer were treated with KIM-guided SABR with 36.25 Gy in 5 fractions. During KIM-guided treatment, the prostate motion was corrected for by either beam gating with couch shifts or multileaf collimator tracking. A dose reconstruction method was used to evaluate the d..
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Awarded by Prostate Cancer Foundation of Australia
Funding Acknowledgements
This work was supported by Cancer Australia (APP1081534), the Prostate Cancer Foundation of Australia, and the National Health & Medical Research Council of Australia (APP1112096, APP1138807).