Journal article

Real-Time Image Guided Ablative Prostate Cancer Radiation Therapy: Results From the TROG 15.01 SPARK Trial

Paul Keall, Doan Trang Nguyen, Ricky O'Brien, Emily Hewson, Helen Ball, Per Poulsen, Jeremy Booth, Peter Greer, Perry Hunter, Lee Wilton, Regina Bromley, John Kipritidis, Thomas Eade, Andrew Kneebone, George Hruby, Trevor Moodie, Amy Hayden, Sandra Turner, Sankar Arumugam, Mark Sidhom Show all

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | ELSEVIER SCIENCE INC | Published : 2020

Abstract

PURPOSE: Kilovoltage intrafraction monitoring (KIM) is a novel software platform implemented on standard radiation therapy systems and enabling real-time image guided radiation therapy (IGRT). In a multi-institutional prospective trial, we investigated whether real-time IGRT improved the accuracy of the dose patients with prostate cancer received during radiation therapy. METHODS AND MATERIALS: Forty-eight patients with prostate cancer were treated with KIM-guided SABR with 36.25 Gy in 5 fractions. During KIM-guided treatment, the prostate motion was corrected for by either beam gating with couch shifts or multileaf collimator tracking. A dose reconstruction method was used to evaluate the d..

View full abstract

Grants

Awarded by Cancer Australia


Awarded by National Health & Medical Research Council of Australia


Funding Acknowledgements

This work was supported by Cancer Australia (APP1081534), the Prostate Cancer Foundation of Australia, and the National Health & Medical Research Council of Australia (APP1112096, APP1138807).