Journal article

Predictive Models for Pulmonary Artery Size in Fontan Patients

Akash Gupta, Chris Gillett, Patrick Gerard, Michael MH Cheung, Jonathan P Mynard, Ethan Kung

Journal of Cardiovascular Translational Research | SPRINGER | Published : 2020

Abstract

We developed models of pulmonary artery (PA) size in Fontan patients as a function of age and body surface area (BSA) using linear regression and breakpoint analyses based on data from 43 Fontan patients divided into two groups: the extracardiac conduit (ECC) group (n = 24) and the non-ECC group (n = 19). Model predictions were compared against those of a non-Fontan control group (n = 18) and published literature. We observed strong positive correlations of the mean PA diameter with BSA (r = 0.9, p < 0.05) and age (r = 0.88, p < 0.05) in the ECC group. The absolute percentage differences between our BSA and age model predictions against published literature were less than 16% and 20%, respec..

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Grants


Funding Acknowledgements

This work was supported by an Award from the American Heart Association, The Children's Heart Foundation, and the Department of Mechanical Engineering at Clemson University. J.P. Mynard is supported by a co-funded Career Development Fellowship from the National Health and Medical Research Council of Australia and a Future Leader Fellowship from the National Heart Foundation. The Heart Research group at MCRI (J.P. Mynard) is supported by the Victorian Government's Operational Infrastructure Support Program, Big W, and RCH1000.