Conference Proceedings
Abstract 245: Heart Failure With Preserved Ejection Fraction-a New Animal Model and a Novel Mechanistic Perspective
Claire L Curl, Vennetia R Danes, James R Bell, Antonia J Raaijmakers, Chanchal Chandramouli, Tristan W Harding, Kimberley M Mellor, Jonathan Kalman, Stephen B Harrap, Lea M Delbridge
CIRCULATION RESEARCH | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
Diagnosis of heart failure with preserved ejection fraction (HFpEF) is becoming the prevalent form of disease type. Established treatments for heart failure with reduced ejection fraction (HFrEF) have proven minimally effective for HFpEF. This may reflect differences in underlying cardiomyocyte pathophysiology. In HFrEF cardiomyocyte phenotype is characterized by impaired contractile response and diminished systolic Ca 2+ levels. Studies of intact HFpEF-derived cardiomyocytes are lacking. Progress in understanding the etiology of HFpEF has been impeded by limited availability of appropriate pre-clinical models. Our goal was to validate and charact..
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