Journal article

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

Lars Fugger, Lise Torp Jensen, Jamie Rossjohn

Cell | CELL PRESS | Published : 2020


Autoimmune diseases are a result of the immune system being misdirected toward its host and have major and increasing unmet clinical needs. In general, present therapies are broadly acting and non-disease specific; consequently, they are associated with numerous side effects. Precise and early intervention strategies are urgently needed. We highlight the challenges, progress, and prospects in achieving these goals.

University of Melbourne Researchers


Awarded by Wellcome Trust

Awarded by Oak Foundation

Awarded by Australian Research Council

Funding Acknowledgements

The authors wish to thank Dr. Kathrine Attfield for helpful discussions. L.F. is supported by the Wellcome Trust (100308/Z/12/Z), the Oak Foundation (OCAY-15-520), the NIHR Oxford BRC, and the MRC UK. J.R. is supported by an Australian Research Council laureate fellowship (FL160100049).