Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases
Lars Fugger, Lise Torp Jensen, Jamie Rossjohn
Cell | CELL PRESS | Published : 2020
Autoimmune diseases are a result of the immune system being misdirected toward its host and have major and increasing unmet clinical needs. In general, present therapies are broadly acting and non-disease specific; consequently, they are associated with numerous side effects. Precise and early intervention strategies are urgently needed. We highlight the challenges, progress, and prospects in achieving these goals.
Awarded by Wellcome Trust
Awarded by Oak Foundation
Awarded by Australian Research Council
The authors wish to thank Dr. Kathrine Attfield for helpful discussions. L.F. is supported by the Wellcome Trust (100308/Z/12/Z), the Oak Foundation (OCAY-15-520), the NIHR Oxford BRC, and the MRC UK. J.R. is supported by an Australian Research Council laureate fellowship (FL160100049).