Journal article

Factors associated with pneumococcal carriage and density in children and adults in Fiji, using four cross-sectional surveys

Eleanor FG Neal, Cattram D Nguyen, Felista T Ratu, Eileen M Dunne, Mike Kama, Belinda D Ortika, Laura K Boelsen, Joseph Kado, Lisi Tikoduadua, Rachel Devi, Evelyn Tuivaga, Rita C Reyburnl, Catherine Satzke, Eric Rafai, Kim Mulholland, Fiona M Russell

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

This study describes predictors of pneumococcal nasopharyngeal carriage and density in Fiji. We used data from four annual (2012-2015) cross-sectional surveys, pre- and post-introduction of ten-valent pneumococcal conjugate vaccine (PCV10) in October 2012. Infants (5-8 weeks), toddlers (12-23 months), children (2-6 years), and their caregivers participated. Pneumococci were detected and quantified using lytA qPCR, with molecular serotyping by microarray. Logistic and quantile regression were used to determine predictors of pneumococcal carriage and density, respectively. There were 8,109 participants. Pneumococcal carriage was negatively associated with years post-PCV10 introduction (global ..

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Grants

Awarded by Bill & Melinda Gates Foundation


Awarded by NHMRC Career Development Fellowship


Funding Acknowledgements

This project was funded by the Bill & Melinda Gates Foundation (grant numbers OPP1126272 and OPP1084341), and the Department of Foreign Affairs and Trade of the Australian Government, the Fiji Health Sector Support Program (implemented by Abt JTA on behalf of the Australian Government), with support from the Victorian Government's Operational Infrastructure Support Program (https://www2.health.vic.gov.au/about/clinical-trials-and-research/operational-infrastructure-support).FMR was supported by a NHMRC Early Career and TRIP Fellowships (https://www.nhmrc.gov.au/).CS was supported by a NHMRC Career Development Fellowship (1087957) and a veski Inspiring Women Fellowship (https://www.veski.org.au/).EFGN holds an Australian Government Research Training Scholarship (https://www.education.gov.au/research-training-program).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.