Journal article
Multifunctional Antibodies Are Induced by the RTS,S Malaria Vaccine and Associated with Protection in a Phase 1/2a Trial
L Kurtovic, T Atre, G Feng, BD Wines, JA Chan, MJ Boyle, DR Drew, PM Hogarth, FJI Fowkes, ES Bergmann-Leitner, JG Beeson
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2021
Open access
Abstract
Background: RTS,S is the leading malaria vaccine candidate but only confers partial efficacy against malaria in children. RTS,S is based on the major Plasmodium falciparum sporozoite surface antigen, circumsporozoite protein (CSP). The induction of anti-CSP antibodies is important for protection; however, it is unclear how these protective antibodies function. Methods: We quantified the induction of functional anti-CSP antibody responses in healthy malaria-naive adults (N = 45) vaccinated with RTS,S/AS01. This included the ability to mediate effector functions via the fragment crystallizable (Fc) region, such as interacting with human complement proteins and Fcγ-receptors (FcγRs) that are ex..
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Funding Acknowledgements
This work was funded by the National Health and Medical Research Council (NHMRC) of Australia (grant to J. G. B., P. M. H., and B. D. W.; fellowships to J. G. B. and F. J. I. F.); National Institutes of Health, the Military Infectious Disease Research Program (to T. A. and E. S. B. L.); Australian Research Training Program Scholarship to L. K.; Monash Postgraduate Publication Award to L. K.; and the Australian Society for Parasitology Network Researcher Exchange, Training and Travel award to L. K. The Burnet Institute is supported by a Victorian State Government Operational Infrastructure Support grant and NHMRC Independent Research Institutes Infrastructure Support Scheme. J. G. B., F. J. I. F., L. K., M. J. B., J. A. C., and G. F. are supported by the Centre for Research Excellence in Malaria Elimination, funded by NHMRC, Australia.