Characteristic Histopathological Findings and Cardiac Arrest Rhythm in Isolated Mitral Valve Prolapse and Sudden Cardiac Death

Hui-Chen Han; Sarah A Parsons; Andrew W Teh; Prashanthan Sanders; Christopher Neil; Trishe Leong; Anoop N Koshy; Jitendra K Vohra; Jonathan M Kalman; Karen Smith; David O'Donnell; David L Hare; Omar Farouque; Han S Lim

Journal article

Characteristic Histopathological Findings and Cardiac Arrest Rhythm in Isolated Mitral Valve Prolapse and Sudden Cardiac Death

Hui-Chen Han, Sarah A Parsons, Andrew W Teh, Prashanthan Sanders, Christopher Neil, Trishe Leong, Anoop N Koshy, Jitendra K Vohra, Jonathan M Kalman, Karen Smith, David O'Donnell, David L Hare, Omar Farouque, Han S Lim

Journal of the American Heart Association | WILEY | Published : 2020

DOI: 10.1161/JAHA.119.015587

Abstract

Background The association between mitral valve prolapse (MVP) and sudden death remains controversial. We aimed to describe histopathological changes in individuals with autopsy-determined isolated MVP (iMVP) and sudden death and document cardiac arrest rhythm. Methods and Results The Australian National Coronial Information System database was used to identify cases of iMVP between 2000 and 2018. Histopathological changes in iMVP and sudden death were compared with 2 control cohorts matched for age, sex, height, and weight (1 group with noncardiac death and 1 group with cardiac death). Data linkage with ambulance services provided cardiac arrest rhythm for iMVP cases. From 77 221 cardiovasc..

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