Characteristic histopathological findings and cardiac arrest rhythm in isolated mitral valve prolapse and sudden cardiac death

HC Han; SA Parsons; AW Teh; P Sanders; C Neil; T Leong; AN Koshy; JK Vohra; JM Kalman; K Smith; D O’donnell; DL Hare; O Farouque; HS Lim

Journal article

Characteristic histopathological findings and cardiac arrest rhythm in isolated mitral valve prolapse and sudden cardiac death

HC Han, SA Parsons, AW Teh, P Sanders, C Neil, T Leong, AN Koshy, JK Vohra, JM Kalman, K Smith, D O’donnell, DL Hare, O Farouque, HS Lim

Journal of the American Heart Association | WILEY | Published : 2020

DOI: 10.1161/JAHA.119.015587

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Abstract

BACKGROUND: The association between mitral valve prolapse (MVP) and sudden death remains controversial. We aimed to describe histopathological changes in individuals with autopsy-determined isolated MVP (iMVP) and sudden death and document cardiac arrest rhythm. METHODS AND RESULTS: The Australian National Coronial Information System database was used to identify cases of iMVP between 2000 and 2018. Histopathological changes in iMVP and sudden death were compared with 2 control cohorts matched for age, sex, height, and weight (1 group with noncardiac death and 1 group with cardiac death). Data linkage with ambulance services provided cardiac arrest rhythm for iMVP cases. From 77 221 cardiova..

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