Journal article

Heterogeneous genetic invasions of three insecticide resistance mutations in Indo-Pacific populations of Aedes aegypti (L.)

Nancy M Endersby-Harshman, Thomas L Schmidt, Jessica Chung, Anthony van Rooyen, Andrew R Weeks, Ary A Hoffmann

Molecular Ecology | WILEY | Published : 2020

Abstract

Nations throughout the Indo-Pacific region use pyrethroid insecticides to control Aedes aegypti, the mosquito vector of dengue, often without knowledge of pyrethroid resistance status of the pest or origin of resistance. Two mutations (V1016G + F1534C) in the sodium channel gene (Vssc) of Ae. aegypti modify ion channel function and cause target-site resistance to pyrethroid insecticides, with a third mutation (S989P) having a potential additive effect. Of 27 possible genotypes involving these mutations, some allelic combinations are never seen whereas others predominate. Here, five allelic combinations common in Ae. aegypti from the Indo-Pacific region are described and their geographical di..

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Grants

Awarded by Wellcome Trust


Awarded by National Health and Medical Research Council


Funding Acknowledgements

Wellcome Trust, Grant/Award Number: 108508; National Health and Medical Research Council, Grant/Award Number: 1037003, 1118640 and 1132412; Department of Agriculture and Water Resources (DAWR), Australian Government