Journal article

Age-related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk

Fei Fei Gong, Jennifer M Coller, Michele McGrady, Umberto Boffa, Louise Shiel, Danny Liew, Simon Stewart, Alice J Owen, Henry Krum, Christopher M Reid, David L Prior, Duncan J Campbell

ESC HEART FAILURE | WILEY PERIODICALS, INC | Published : 2020

Abstract

AIM: Heart failure (HF) incidence increases markedly with age. We examined age-associated longitudinal change in cardiac structure and function, and their prediction by age and cardiovascular disease (CVD) risk factors, in a community-based cohort aged ≥60 years at increased CVD risk but without HF. METHODS AND RESULTS: CVD risk factors were recorded in 3065 participants who underwent a baseline echocardiographic examination, of whom 2358 attended a follow-up examination 3.8 [median, inter-quartile range (IQR) 3.5, 4.2] years later. Median age was 71 (IQR 67, 76) years and 55% of participants were male. Age was associated with longitudinal increase in left ventricular (LV) mass index (LVMI);..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Heart Foundation of Australia


Awarded by Diabetes Australia Research Trust


Funding Acknowledgements

This work was supported by Bupa Health Foundation, Australia, with subsequent support from the National Health and Medical Research Council of Australia (GTN0559010, GTN1044619, and GTN0395508 to D.J.C.; GTN1092642 to H. K.; GTN1045862 and GTN1136372 to C.M.R.; GTN1041796 to S.S.; GTN0620241 to J.M.C.; GNT0519456 to M.M.), the National Heart Foundation of Australia (G 07M 3198), the Diabetes Australia Research Trust (Y15G-CAMD), the University of Melbourne, St. Vincent's Hospital Melbourne, St. Vincent's Institute of Medical Research, and the Victorian Government's Operational Infrastructure Support Program.