Journal article

High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4

Guang-yao Lin, Lin Lin, Xiao-qing Cai, An-tao Dai, Yue Zhu, Jie Li, Qing Liu, De-hua Yang, Ross AD Bathgate, Ming-wei Wang

Acta Pharmacologica Sinica | NATURE PUBLISHING GROUP | Published : 2020

Grants

Awarded by National Natural Science Foundation of China


Awarded by National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China


Awarded by National Key R&D Program of China


Awarded by Novo Nordisk-CAS Research Fund


Funding Acknowledgements

We are indebted to Ji Wu and Qiang Shen for technical assistance. This work was partially supported by grants from the National Natural Science Foundation of China 81872915 (MWW), 81573479 (DHY), and 81773792 (DHY); the National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China (2018ZX09735-001 to MWW, 2018ZX09711002-002-005 to DHY and 2018ZX09711002-002-011 to QL); the National Key R&D Program of China 2018YFA0507000 (MWW); and the Novo Nordisk-CAS Research Fund (NNCAS-2017-1-CC to DHY). Research at the Florey was supported by the Victorian Government's Operational Infrastructure Support Program. We are grateful to Tania Ferraro and Sharon Layfield for assistance with assays at the Florey. RADB is an NHMRC Senior Research Fellow. The funders had no role in the study design, data collection and analysis, decision to publish, or paper preparation.