Journal article

Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression

Yuri Milaneschi, Femke Lamers, Michael Berk, Brenda WJH Penninx

Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2020

Abstract

Epidemiological evidence indicates the presence of dysregulated homeostatic biological pathways in depressed patients, such as increased inflammation and disrupted energy-regulating neuroendocrine signaling (e.g., leptin, insulin). Alterations in these biological pathways may explain the considerable comorbidity between depression and cardiometabolic conditions (e.g., obesity, metabolic syndrome, diabetes) and represent a promising target for intervention. This review describes how immunometabolic dysregulations vary as a function of depression heterogeneity by illustrating that such biological dysregulations map more consistently to atypical behavioral symptoms reflecting altered energy int..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council Senior Principal Research Fellowship


Awarded by European Union Seventh Framework Programme FP7-Marie Curie Career Integration Grant


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council Senior Principal Research Fellowship (Grant Nos. APP1059660 and APP1156072 [to MB]) and European Union Seventh Framework Programme FP7-Marie Curie Career Integration Grant (Grant No. PCIG12-GA-2012-334065 [to FL]).