Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression
Yuri Milaneschi, Femke Lamers, Michael Berk, Brenda WJH Penninx
Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2020
Epidemiological evidence indicates the presence of dysregulated homeostatic biological pathways in depressed patients, such as increased inflammation and disrupted energy-regulating neuroendocrine signaling (e.g., leptin, insulin). Alterations in these biological pathways may explain the considerable comorbidity between depression and cardiometabolic conditions (e.g., obesity, metabolic syndrome, diabetes) and represent a promising target for intervention. This review describes how immunometabolic dysregulations vary as a function of depression heterogeneity by illustrating that such biological dysregulations map more consistently to atypical behavioral symptoms reflecting altered energy int..View full abstract
Awarded by National Health and Medical Research Council Senior Principal Research Fellowship
Awarded by European Union Seventh Framework Programme FP7-Marie Curie Career Integration Grant
This work was supported by the National Health and Medical Research Council Senior Principal Research Fellowship (Grant Nos. APP1059660 and APP1156072 [to MB]) and European Union Seventh Framework Programme FP7-Marie Curie Career Integration Grant (Grant No. PCIG12-GA-2012-334065 [to FL]).