Thermal damage threshold of neurons during infrared stimulation
WGA Brown, K Needham, JM Begeng, AC Thompson, BA Nayagam, T Kameneva, PR Stoddart
Biomedical Optics Express | OSA - Optical Society of America | Published : 2020
In infrared neural stimulation (INS), laser-evoked thermal transients are used to generate small depolarising currents in neurons. The laser exposure poses a moderate risk of thermal damage to the target neuron. Indeed, exogenous methods of neural stimulation often place the target neurons under stressful non-physiological conditions, which can hinder ordinary neuronal function and hasten cell death. Therefore, quantifying the exposure-dependent probability of neuronal damage is essential for identifying safe operating limits of INS and other interventions for therapeutic and prosthetic use. Using patch-clamp recordings in isolated spiral ganglion neurons, we describe a method for determinin..View full abstract
Related Projects (1)
Awarded by Australian Research Council
Australian Research Council Linkage Project (LP120100264).