Journal article

Thermal damage threshold of neurons during infrared stimulation

WGA Brown, K Needham, JM Begeng, AC Thompson, BA Nayagam, T Kameneva, PR Stoddart

Biomedical Optics Express | OSA - Optical Society of America | Published : 2020

Abstract

In infrared neural stimulation (INS), laser-evoked thermal transients are used to generate small depolarising currents in neurons. The laser exposure poses a moderate risk of thermal damage to the target neuron. Indeed, exogenous methods of neural stimulation often place the target neurons under stressful non-physiological conditions, which can hinder ordinary neuronal function and hasten cell death. Therefore, quantifying the exposure-dependent probability of neuronal damage is essential for identifying safe operating limits of INS and other interventions for therapeutic and prosthetic use. Using patch-clamp recordings in isolated spiral ganglion neurons, we describe a method for determinin..

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