MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network.

Giovanni Battista Migliori; Simon Tiberi; Alimuddin Zumla; Eskild Petersen; Jeremiah Muhwa Chakaya; Christian Wejse; Marcela Muñoz Torrico; Raquel Duarte; Jan Willem Alffenaar; H Simon Schaaf; Ben J Marais; Daniela Maria Cirillo; Riccardo Alagna; Adrian Rendon; Emanuele Pontali; Alberto Piubello; José Figueroa; Gabriella Ferlazzo; Alberto García-Basteiro; Rosella Centis; Dina Visca; Lia D'Ambrosio; Giovanni Sotgiu; members of the Global Tuberculosis Network

Journal article

MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network.

Giovanni Battista Migliori, Simon Tiberi, Alimuddin Zumla, Eskild Petersen, Jeremiah Muhwa Chakaya, Christian Wejse, Marcela Muñoz Torrico, Raquel Duarte, Jan Willem Alffenaar, H Simon Schaaf, Ben J Marais, Daniela Maria Cirillo, Riccardo Alagna, Adrian Rendon, Emanuele Pontali, Alberto Piubello, José Figueroa, Gabriella Ferlazzo, Alberto García-Basteiro, Rosella Centis Show all

International Journal of Infectious Diseases | Published : 2020

DOI: 10.1016/j.ijid.2020.01.042

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Abstract

The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment..

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