MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

GB Migliori; S Tiberi; A Zumla; E Petersen; JM Chakaya; C Wejse; MM Torrico; R Duarte; JW Alffenaar; HS Schaaf; BJ Marais; DM Cirillo; R Alagna; A Rendon; E Pontali; A Piubello; J Figueroa; G Ferlazzo; A García-Basteiro; R Centis; D Visca; L D’Ambrosio; G Sotgiu; T Abu Arkub; OW Akkerman; A Aleksa; E Belilovski; E Bernal; FX Blanc; M Boeree; S Borisov; J Bruchfeld; J Cadiñanos Loidi; JA Caminero; AC Carvalho; JJ Cebrian Gallardo; M Charalampos; E Danila; L Davies Forsman; J Denholm; K Dheda; R Diel; S Diktanas; C Dobler; M Enwerem; S Esposito; N Escobar Salinas; A Filippov; B Formenti; JM García García; D Goletti; R Gomez Rosso; G Gualano; P Isaakidis; A Kaluzhenina; S Koirala; L Kuksa; H Kunst; Y Li; C Magis-Escurra; V Manfrin; S Manga; K Manika; V Marchese; E Martínez Robles; A Maryandyshev; A Matteelli; A Mariani; J Mazza-Stalder; F Mello; L Mendoza; A Mesi; S Miliauskas; H Mustafa Hamdan; N Ndjeka; M Nieto Marcos; THM Ottenhoff; DJ Palmero; F Palmieri; A Papavasileiou; MC Payen; A Pontarelli; M Pretti Dalcolmo; S Quirós Fernandez; R Romero; D Rossato Silva; AP Santos; B Seaworth; M Sinitsyn; A Skrahina; I Solovic; A Spanevello; M Tadolini; C Torres; Z Udwadia; M van den Boom; GV Volchenkov; A Yedilbayev; R Zaleskis; JP Zellweger

Journal article

MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

GB Migliori, S Tiberi, A Zumla, E Petersen, JM Chakaya, C Wejse, MM Torrico, R Duarte, JW Alffenaar, HS Schaaf, BJ Marais, DM Cirillo, R Alagna, A Rendon, E Pontali, A Piubello, J Figueroa, G Ferlazzo, A García-Basteiro, R Centis Show all

International Journal of Infectious Diseases | Published : 2020

DOI: 10.1016/j.ijid.2020.01.042

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Abstract

The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment..

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