Journal article

Early net ultrafiltration rate and mortality in critically ill patients receiving continuous renal replacement therapy

Thummaporn Naorungroj, Ary Serpa Neto, Lara Zwakman-Hessels, Fumitaka Yanase, Glenn Eastwood, Raghavan Murugan, John A Kellum, Rinaldo Bellomo

NEPHROLOGY DIALYSIS TRANSPLANTATION | OXFORD UNIV PRESS | Published : 2021

Abstract

BACKGROUND: In patients treated with continuous renal replacement therapy (CRRT), early net ultrafiltration (NUF) rates may be associated with differential outcomes. We tested whether higher early NUF rates are associated with increased mortality in CRRT patients. METHODS: We performed a retrospective, observational study of all patients treated with CRRT within 14 days of intensive care unit admission. We defined the early (first 48 h) NUF rate as the volume of fluid removed per hour adjusted for patient body weight and analysed as a categorical variable (>1.75, 1.01-1.75 and <1.01 mL/kg/h). The primary outcome was 28-day mortality. To deal with competing risk, we also compared different ti..

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