Journal article

Effect of inorganic nitrate on exercise capacity, mitochondria respiration, and vascular function in heart failure with reduced ejection fraction

Mary N Woessner, Christopher Neil, Nicholas J Saner, Craig A Goodman, Luke C McIlvenna, Joaquin Ortiz de Zevallos, Andrew Garnham, Itamar Levinger, Jason D Allen

Journal of Applied Physiology | AMER PHYSIOLOGICAL SOC | Published : 2020

Abstract

Chronic underperfusion of the skeletal muscle tissues is a contributor to a decrease in exercise capacity in patients with heart failure with reduced ejection fraction (HFrEF). This underperfusion is due, at least in part, to impaired nitric oxide (NO) bioavailability. Oral inorganic nitrate supplementation increases NO bioavailability and may be used to improve exercise capacity, vascular function, and mitochondrial respiration. Sixteen patients with HFrEF (fifteen men, 63 ± 4 yr, body mass index: 31.8 ± 2.1 kg/m2) participated in a randomized, double-blind, crossover design study. Following consumption of either nitrate-rich beetroot juice (16 mmol nitrate/day) or a nitrate-depleted placeb..

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Grants

Awarded by National Heart Foundation of Australia Vanguard Grant


Funding Acknowledgements

This work was supported by National Heart Foundation of Australia Vanguard Grant 101389 and an internal Victoria University Central Research Grant Scheme Award.