Journal article

Dissociated roles of dorsal and ventral hippocampus in recall and extinction of conditioned fear in male and female juvenile rats

Chun Hui J Park, Despina E Ganella, Christina J Perry, Jee Hyun Kim

Experimental Neurology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020

Abstract

Reduction of conditioned fear expression by extinction underlies cue exposure therapies that treat anxiety disorders. Extinction is context-specific. Renewal, for example, is the relapse of extinguished fear when subjects are tested in a different context to extinction. This context-specificity is developmentally regulated and sex-dependent, with renewal being observed in postnatal day (P) 18 female, but not in male, rats. Given the hippocampus (HPC) is critical for context-specific extinction in adult rodents, we investigated dorsal or ventral hippocampus (dHPC or vHPC) involvement in context-specific extinction in P18 male and female rats. We microinfused muscimol (GABAA agonist) to inacti..

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Grants

Awarded by National Health and Medical Research Council Career Development Fellowship


Awarded by Australian Research Council


Funding Acknowledgements

This work was supported by a Baker Foundation Fellowship awarded to DEG, National Health and Medical Research Council Career Development Fellowship (1083309) and Australian Research Council Discovery Grant (50102496) awarded to JHK.