Dissociated roles of dorsal and ventral hippocampus in recall and extinction of conditioned fear in male and female juvenile rats
Chun Hui J Park, Despina E Ganella, Christina J Perry, Jee Hyun Kim
Experimental Neurology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020
Reduction of conditioned fear expression by extinction underlies cue exposure therapies that treat anxiety disorders. Extinction is context-specific. Renewal, for example, is the relapse of extinguished fear when subjects are tested in a different context to extinction. This context-specificity is developmentally regulated and sex-dependent, with renewal being observed in postnatal day (P) 18 female, but not in male, rats. Given the hippocampus (HPC) is critical for context-specific extinction in adult rodents, we investigated dorsal or ventral hippocampus (dHPC or vHPC) involvement in context-specific extinction in P18 male and female rats. We microinfused muscimol (GABAA agonist) to inacti..View full abstract
Awarded by National Health and Medical Research Council Career Development Fellowship
Awarded by Australian Research Council
This work was supported by a Baker Foundation Fellowship awarded to DEG, National Health and Medical Research Council Career Development Fellowship (1083309) and Australian Research Council Discovery Grant (50102496) awarded to JHK.