Journal article

Infant microbiota in colic: predictive associations with problem crying and subsequent child behavior

Amy Loughman, Thomas Quinn, Monica L Nation, Amy Reichelt, Robert J Moore, Thi Thu Hao Van, Valerie Sung, Mimi LK Tang

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE | CAMBRIDGE UNIV PRESS | Published : 2021

Abstract

Infant colic is a condition of unknown cause which can result in carer distress and attachment difficulties. Recent studies have implicated the gut microbiota in infant colic, and certain probiotics have demonstrated possible efficacy. We aim to investigate whether the intestinal microbiota composition in infants with colic is associated with cry/fuss time at baseline, persistence of cry/fuss at 4-week follow-up, or child behavior at 2 years of age. Fecal samples from infants with colic (n = 118, 53% male) were analyzed using 16S rRNA sequencing. After examining the alpha and beta diversity of the clinical samples, we performed a differential abundance analysis of the 16S data to look for ta..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC) Early Career Fellowship


Funding Acknowledgements

The original Baby Biotics study was funded by theMurdoch Children's Research Institute, Royal Children's HospitalMelbourne (Australia) Centre for Community Child Health and the Georgina Menzies Maconachie Charitable Trust administered by Equity Trustees. The 16S sequencing was funded by an RMIT University Transitional Seed Grant awarded to Dr Amy Loughman, Dr Amy Reichelt, Professor Robert J Moore, and Dr Michelle Rank. AL is supported by theWilson Foundation. Dr Valerie Sung was supported by Australian National Health and Medical Research Council (NHMRC) Early Career Fellowship [1125687]; research at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program.