Early life acetaminophen exposure, glutathione S-transferase genes, and development of adolescent asthma in a high-risk birth cohort
Xin Dai, Shyamali C Dharmage, Michael J Abramson, Bircan Erbas, Catherine M Bennett, Cecilie Svanes, Jennie Hui, Christine Axelrad, Adrian J Lowe, Caroline J Lodge
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | MOSBY-ELSEVIER | Published : 2020
BACKGROUND: Although the impact of early life acetaminophen on asthma risk is still not clear, potential interactions with glutathione S-transferase (GST) genes due to reduced antioxidant function in particular polymorphisms, and possible impact on lung function, have never been investigated in adolescents. OBJECTIVE: We aimed to investigate associations between early life acetaminophen use and adolescent asthma and lung function and to assess potential interactions by GST polymorphisms. METHODS: Acetaminophen use was recorded 18 times up to age 2 years (n = 575 [92.7%]). Participants were genotyped for GST polymorphisms (GSTM1/T1/P1) (n = 429 [69.2%]). Asthma and lung function were measured..View full abstract
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
The first 6 years of the Melbourne Atopy Cohort Study were funded (study formula and staff) by Nestec Ltd, a subsidiary of Nestle Australia. The 12-year follow-up was funded by a project grant from the Asthma Foundation of Victoria. The National Health and Medical Research Council of Australia (NHMRC) funded the 18-year follow-up (grant no. APP454856). X.D., S.C.D., A.J.L., and C.J.L. are funded by the NHMRC.