Journal article

The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

William T O'Brien, Louise Pham, Georgia F Symons, Mastura Monif, Sandy R Shultz, Stuart J McDonald

Journal of Neuroinflammation | BMC | Published : 2020

Abstract

There is a great clinical need to identify the underlying mechanisms, as well as related biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a central pathophysiological feature of TBI. NLRP3 inflammasome activity is a necessary component of the innate immune response to tissue damage, and dysregulated inflammasome activity has been implicated in a number of neurological conditions. This paper introduces the NLRP3 inflammasome and its implication in the pathogenesis of neuroinflammatory-related conditions, with a particular focus on TBI. Although its role in TBI has only recently been identified, findings suggest that priming and activation of the NLRP3 ..

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