Journal article
The association between intravitreal ranibizumab therapy and serum cytokine concentrations in patients with diabetic macular edema
S Gnanasekaran, E Bandala-Sanchez, M Kolic, L Churilov, SL Rogers, AK McAuley, SS Sandhu, S Qureshi, LL Lim, SS Wickremasinghe
Molecular Vision | MOLECULAR VISION | Published : 2020
Abstract
Aim: To investigate the association between intravitreal ranibizumab therapy and serum cytokine concentrations in patients with diabetic macular edema (DME). Methods: Twenty-five patients with center-involved DME were recruited prospectively. Serum samples were collected from the patients before and 4 weeks after two ranibizumab injections. The levels of 32 cytokines at these two time points were assessed using a multiplex array assay. Results: Following two ranibizumab injections, there was a statistically significant decrease in the median [interquartile range] levels of Interleukin 1-1beta (IL-1β) from 5.56 [3.6, 8.75] to 2.33 [1.51, 2.89], Interleukin 13 (IL-13) from 4.30 [1.84, 18.55] t..
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Awarded by Novartis Pharma
Funding Acknowledgements
Funding sources: This study was supported by a grant from Novartis Pharma AG. SW (GNT 1128343) and LLL (GNT 1109330) are supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowships. The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government.