Journal article

The business impact of an integrated continuous biomanufacturing platform for recombinant protein production

Jason Walther, Rahul Godawat, Chris Hwang, Yuki Abe, Andrew Sinclair, Konstantin Konstantinov

Journal of Biotechnology | ELSEVIER SCIENCE BV | Published : 2015

Abstract

The biotechnology industry primarily uses batch technologies to manufacture recombinant proteins. The natural evolution of other industries has shown that transitioning from batch to continuous processing can yield significant benefits. A quantitative understanding of these benefits is critical to guide the implementation of continuous processing. In this manuscript, we use process economic modeling and Monte Carlo simulations to evaluate an integrated continuous biomanufacturing (ICB) platform and conduct risk-based valuation to generate a probabilistic range of net-present values (NPVs). For a specific ten-year product portfolio, the ICB platform reduces average cost by 55% compared to con..

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