Disposable membrane chromatography - Counting the cost

Abstract

Membrane technology is cited as one of the most exciting current market trends in the biopharmaceutical industry. This article examines the principles of membrane chromatography and expands on a recent cost model, that compares the direct and indirect costs of membrane and traditional column chromatography modules in a commonly used polishing step - anion exchange chromatography (AEX) for the purification of monoclonal antibodies (MAbs). The economic model includes a detailed examination of the materials, labor, upfront equipment costs, and running expenses, as well as some of the more intangible benefits this technology provides.