Journal article

Exactly solvable models of stochastic gene expression

Lucy Ham, David Schnoerr, Rowan Brackston, Michael Stumpf

Published : 2020

Abstract

Stochastic models are key to understanding the intricate dynamics of gene expression. But the simplest models which only account for e.g. active and inactive states of a gene fail to capture common observations in both prokaryotic and eukaryotic organisms. Here we consider multistate models of gene expression which generalise the canonical Telegraph process, and are capable of capturing the joint effects of e.g. transcription factors, heterochromatin state and DNA accessibility (or, in prokaryotes, Sigma-factor activity) on transcript abundance. We propose two approaches for solving classes of these generalised systems. The first approach offers a fresh perspective on a general class of mult..

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University of Melbourne Researchers

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