Journal article

Reconciling Epigenetic Memory and Transcriptional Responsiveness.

Amanda G Fisher, Michael PH Stumpf, Matthias Merkenschlager

Cell Systems | Published : 2017

Abstract

The molecular basis of cellular memory is important but poorly understood. Using estimates of histone dynamics, Martin Howard and colleagues construct a mathematical model that helps to explain both the stability and flexibility of Polycomb-mediated gene regulation in cellular memory.

University of Melbourne Researchers

Grants

Awarded by Medical Research Council