The ABC of reverse engineering biological signalling systems.

Abstract

Modelling biological systems would be straightforward if we knew the structure of the model and the parameters governing their dynamics. For the overwhelming majority of biological processes, however, such parameter values are unknown and often impossible to measure directly. This means that we have to estimate or infer these parameters from observed data. Here we argue that it is also important to appreciate the uncertainty inherent in these estimates. We discuss a statistical approach--approximate Bayesian computation (ABC)--which allows us to approximate the posterior distribution over parameters and show how this can add insights into our understanding of the system dynamics. We illustra..