Recombination hotspots as a point process.
Maria De Iorio, Eric de Silva, Michael PH Stumpf
Philosophical Transactions of the Royal Society B: Biological Sciences | Published : 2005
The variation of the recombination rate along chromosomal DNA is one of the important determinants of the patterns of linkage disequilibrium. A number of inferential methods have been developed which estimate the recombination rate and its variation from population genetic data. The majority of these methods are based on modelling the genealogical process underlying a sample of DNA sequences and thus explicitly include a model of the demographic process. Here we propose a different inferential procedure based on a previously introduced framework where recombination is modelled as a point process along a DNA sequence. The approach infers regions containing putative hotspots based on the infer..View full abstract